PRNP
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Major prion protein
The major prion protein (PrP) is encoded in the human body by the PRNP gene also known as CD230 (cluster of differentiation 230). Expression of the protein...
Fatal insomnia
familial (fatal familial insomnia [FFI]), stemming from a mutation in the PRNP gene, with the remainder of cases occurring sporadically (sporadic fatal...
Transmissible spongiform encephalopathy
idiopathic. Genetic (inherited) prion diseases result from rare mutations in PRNP, the gene that codes for PrP (see Genetics, below). Unlike conventional infectious...
Gerstmann–Sträussler–Scheinker syndrome
transmissible spongiform encephalopathies (TSE) due to the causative role played by PRNP, the human prion protein. It was first reported by the Austrian physicians...
Kuru (disease)
called prion (PrP). Prion proteins are encoded by the Prion Protein Gene (PRNP). The two forms of prion are designated as PrPC, which is a normally folded...
PrP systemic amyloidosis
and death. PrP systemic amyloidosis is caused by a genetic truncation of PRNP. There is concern of potential iatrogenic transmission, as bowel symptoms...
Creutzfeldt–Jakob disease
disease phenotype are influenced by a common polymorphism at codon 129 of the PRNP gene (methionine/valine). Notably, individuals homozygous at codon 129 are...
Variant Creutzfeldt–Jakob disease
this can be found in the genetics of people with the disease. The human PRNP protein which is subverted in prion disease can occur with either methionine...
United Kingdom BSE outbreak
a particular genetic makeup; those who were methionine-homozygous at the PRNP codon 129 methionine/valine polymorphism. Studies of similar diseases in...
Prion
evidence that PrP may play a role in innate immunity, as the expression of PRNP, the PrP gene, is upregulated in many viral infections and PrP has antiviral...